Translation of "caspase" to English language:
Examples (External sources, not reviewed)
| Apoptose Bcl 2 Apoptossomo Proteólise The caspase gallery | The Mechanisms of Apoptosis Kimball's Biology Pages. |
| Tipos de proteínas caspase Existem dois tipos de caspases caspases iniciadoras e caspases efetoras. | There are two types of apoptotic caspases initiator (apical) caspases and effector (executioner) caspases. |
| Apesar disso, a função de ICAD DFF45 é retringir a enzima CAD (Dnase Ativada por Caspase). | However, ICAD DFF45 acts to restrain CAD (caspase activated DNase). |
| Horvitz e seu colega Junying Yuan descobriram em 1993 que a proteína codificada pelo gene ced 3 era uma protease baseada em cisteína com propriedades similares a enzima de mamíferos conversora interleukin 1 beta (ICE) (agora conhecida como caspase 1) que na época era a única caspase conhecida. | Horvitz and his colleague Junying Yuan found in 1993 that the protein encoded by the ced 3 gene is cysteine protease with similar properties to the mammalian interleukin 1 beta converting enzyme (ICE) (now known as caspase 1), which at the time was the only known caspase. |
| A clivagem e ainativação de ICAD DFF45 por uma caspase possibilita que CAD entre no núcleo e fragmente o DNA, causando a característica 'escada de DNA' vista nas células apoptóticas. | The cleavage and inactivation of ICAD DFF45 by a caspase allows CAD to enter the nucleus and fragment the DNA, causing the characteristic 'DNA ladder' in apoptotic cells. |
| Ironicamente, apesar de ICE ser a primeira caspase de mamíferos a ser caracterizada devido a sua similaridade com o gene da morte ced 3, o principal papel desta enzima parece ser mediar inflamação ao invés de ser na morte celular. | ICE was the first mammalian caspase to be characterised because of its similarity to the nematode death gene ced 3, but it appears that the principal role of this enzyme is to mediate inflammation rather than cell death. |
| A cascata das caspases pode ser ativada pela granzima B liberada por linfócitos T citotóxicos que ativam caspases 3 e 7 receptores de morte (como o ligante FAS, o TRAIL e o TNF) que podem ativar caspases 8 e 10 e o apoptossomo, regulado pelo citocromo c e a família bcl 2, que ativa a caspase 9. | The caspase cascade can be activated by granzyme B (released by cytotoxic T lymphocytes and NK cells), which is known to activate caspase 3 and 7 death receptors (like Fas, TRAIL receptors and TNF receptor), which can activate caspase 8 and 10 the apoptosome (regulated by cytochrome c and the Bcl 2 family), which activates caspase 9. |
